WASHINGTON (AP) — Republicans are blasting President Joe Biden, threatening lawsuits and going as far as to call for civil disobedience to block his new vaccination mandates.

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It's all in response to his sweeping new federal vaccine requirements that would force as many as 100 million Americans to be vaccinated against COVID-19, or risk losing their jobs.

Biden's move marks a dramatic escalation in the federal government’s campaign against the virus as the highly contagious delta variant continues to spread.

It also sets the stage for a new, more caustic chapter in the COVID culture wars, which have thus far focused mainly on masking mandates.

LOOK: Answers to 30 common COVID-19 vaccine questions

While much is still unknown about the coronavirus and the future, what is known is that the currently available vaccines have gone through all three trial phases and are safe and effective. It will be necessary for as many Americans as possible to be vaccinated in order to finally return to some level of pre-pandemic normalcy, and hopefully these 30 answers provided here will help readers get vaccinated as soon they are able.